A good definition essay is required to have a strong thesis statement in which the point of view of the author on a certain term is revealed. Ordinarily, the term is given the general basic definition implying that the dictionary definitions must be only a start for the author’s unique definition of the term. In order to make a definition essay professionally it is necessary to find a definition of the term that corresponds to the opinion of the author. The definition is always given in own words and specifies what meaning of the term is to be analyzed.
Taken as such, increases in leptin levels (in response to caloric intake) function as an acute pro-inflammatory response mechanism to prevent excessive cellular stress induced by overeating. When high caloric intake overtaxes the ability of fat cells to grow larger or increase in number in step with caloric intake, the ensuing stress response leads to inflammation at the cellular level and ectopic fat storage, ., the unhealthy storage of body fat within internal organs, arteries, and/or muscle. The insulin increase in response to the caloric load provokes a dose-dependent rise in leptin, an effect potentiated by high cortisol levels.  (This insulin-leptin relationship is notably similar to insulin's effect on the increase of IL-6 gene expression and secretion from preadipocytes in a time- and dose-dependent manner.)  Furthermore, plasma leptin concentrations have been observed to gradually increase when acipimox is administered to prevent lipolysis , concurrent hypocaloric dieting and weight loss notwithstanding.  Such findings appear to demonstrate high caloric loads in excess of storage rate capacities of fat cells lead to stress responses that induce an increase in leptin, which then operates as an adipose-derived inflammation stopgap signaling for the cessation of food intake so as to prevent adipose-derived inflammation from reaching elevated levels. This response may then protect against the harmful process of ectopic fat storage, which perhaps explains the connection between chronically elevated leptin levels and ectopic fat storage in obese individuals. 
I am a successful writer, and have been since 1958 when I sold me first story and screenplay. I live in Huntington Beach at the beach with my wife Robbin. I write between six and eight hours daily. I will be 86 in two months. I work out at the gym for one and a half hours six times a week from 3 am to 4:30 am. Sometimes I work out seven days. Not only does everyone say I look as if I'm in my mid-60s, my energy level is similar to my wife's, who is 57 and runs five miles daily. My reason for sharing this with you is that I want everyone to feel as great as I do, without taking all kinds of pills that "supposedly" increase your brain power and physical abilities. See you ate the gym, hugs, Steve